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Target
Non-receptor tyrosine-protein kinase TYK2
Ligand
BDBM633336
Substrate
n/a
Meas. Tech.
TYK2 (TYK2/JAK2 PSTAT4 T-BLAST) Alpha Screen Assay
EC50
8.00±n/a nM
Citation
 Argiriadi, MA; Breinlinger, EC; Chien, EY; Cowart, MD; Frank, KE; Friedman, MM; Hardee, DJ; Herold, JM; Liu, H; Qiu, W; Scanio, MJ; Schrimpf, MR; Vargo, TR; Van Epps, SA; Webster, MP; Little, AJ; Katcher, MH INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING US Patent  US20190276450 Publication Date 9/12/2019 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2
Type:
Protein
Mol. Mass.:
133666.03
Organism:
Homo sapiens (Human)
Description:
P29597
Residue:
1187
Sequence:
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM633336
Synonyms:
US20190276450, Example 17.3
Type:
Small organic molecule
Emp. Form.:
C25H25F2N5O3
Mol. Mass.:
481.4945
SMILES:
CO[C@]1(CCOC1)c1cc(cc(n1)-c1cn([C@@H]2C[C@@H](C2)C#N)c2cnc(NC(C)=O)cc12)C(F)F |r,wU:16.17,18.22,wD:2.1,(2.14,7.81,;1.74,6.32,;.26,5.92,;.73,7.39,;-.51,8.29,;-1.76,7.39,;-1.28,5.92,;1.34,4.83,;2.83,5.23,;3.92,4.14,;3.52,2.65,;2.03,2.26,;.95,3.34,;1.64,.77,;2.54,-.48,;1.64,-1.72,;2.03,-3.21,;1.26,-4.55,;2.6,-5.32,;3.37,-3.98,;3,-6.8,;3.4,-8.29,;.17,-1.25,;-1.16,-2.02,;-2.5,-1.25,;-2.5,.29,;-3.83,1.06,;-5.16,.29,;-6.5,1.06,;-5.16,-1.25,;-1.16,1.06,;.17,.29,;5.41,4.54,;6.5,3.45,;5.81,6.03,)|
Structure:
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