Reaction Details Report a problem with these data
Target
Casein kinase I isoform alpha
Ligand
BDBM10839
Substrate
Casein
Meas. Tech.
Kinase Inhibition Assay
Temperature
303.15±n/a K
IC50
1000±n/a nM
Comments
extracted
Citation
 Gompel, M; Leost, M; De Kier Joffe, EB; Puricelli, L; Franco, LH; Palermo, J; Meijer, L Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. Bioorg Med Chem Lett 14:1703-7 (2004) [PubMed]  Article 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | Casein Kinase I | Csnk1a1 | KC1A_RAT
Type:
Enzyme
Mol. Mass.:
37514.97
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
325
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQGKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF
  
Inhibitor
Name:
BDBM10839
Synonyms:
3-(2-aminopyrimidin-4-yl)-6-bromo-1H-indol-4-ol | Meridianin B
Type:
Small organic molecule
Emp. Form.:
C12H9BrN4O
Mol. Mass.:
305.13
SMILES:
Nc1nccc(n1)-c1c[nH]c2cc(Br)cc(O)c12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Casein
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
20807.68
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
177
Sequence:
MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQTDEIKDTRNESTQNCVVAESEKMESSISSSSEEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW