Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50118886
Substrate
n/a
Meas. Tech.
Biochemical assay
Ki
3200000±n/a nM
Citation
 Silverman, RB; Le, HV; Hawker, DD Tetrahydrothiophene-based GABA aminotransferase inactivators US Patent  US10189807 Publication Date 1/29/2019 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
(S)-3-amino-2-methylpropionate transaminase | 4-aminobutyrate aminotransferase, mitochondrial | ABAT | GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | GABAT | GABT_HUMAN | Gamma-amino-N-butyrate transaminase | L-AIBAT
Type:
PROTEIN
Mol. Mass.:
56449.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459248
Residue:
500
Sequence:
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
  
Inhibitor
Name:
BDBM50118886
Synonyms:
4-Amino-hex-5-enoic acid | CHEMBL89598 | US10189807, (S)-vigabatrin | VIGABATRIN
Type:
Small organic molecule
Emp. Form.:
C6H11NO2
Mol. Mass.:
129.157
SMILES:
NC(CCC(O)=O)C=C
Structure:
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