Reaction Details Report a problem with these data
Target
Apolipoprotein L1
Ligand
BDBM615107
Substrate
n/a
Meas. Tech.
Trypanosoma brucei Brucei Lysis Assay
IC50
600±n/a nM
Citation
 CAO, J; COME, JH; DAKIN, LA; DENIS, F; DORSCH, WA; FORTIER, A; HAMEL, M; KRUEGER, EB; LEDFORD, B; NANTHAKUMAR, SS; NICOLAS, O; SAYEGH, C; SENTER, TJ; WANG, T; BRODNEY, M; HU, K; ROSE, P; GAGNON, K; SHI, Y; SHRESTHA, M; MEDEK, A; WITKOS, F INHIBITORS OF APOL1 AND METHODS OF USING SAME US Patent  US20230271945 Publication Date 8/31/2023 
Target
Name:
Apolipoprotein L1
Synonyms:
APOL | APOL1 | APOL1_HUMAN | Apo-L | ApoL-I | Apolipoprotein L | Apolipoprotein L-I | Apolipoprotein L1
Type:
PROTEIN
Mol. Mass.:
43969.63
Organism:
Homo sapiens
Description:
ChEMBL_120089
Residue:
398
Sequence:
MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
  
Inhibitor
Name:
BDBM615107
Synonyms:
US20230271945, Compound 26
Type:
Small organic molecule
Emp. Form.:
C21H19F2N3O3
Mol. Mass.:
399.3907
SMILES:
O[C@@H]1CNC(=O)[C@H]1NC(=O)CCc1c([nH]c2c(F)cc(F)cc12)-c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: