Reaction Details Report a problem with these data
Target
Transcription initiation factor TFIID subunit 1 [1381-1497]
Ligand
BDBM346460
Substrate
n/a
Meas. Tech.
TAF1-BD1 TR-FRET Binding Assay
IC50
184±n/a nM
Citation
 Adler, M; Burdick, DJ; Crawford, T; Duplessis, M; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Tsui, VH; Wang, S Therapeutic compounds and uses thereof US Patent  US10202378 Publication Date 2/12/2019 
Target
Name:
Transcription initiation factor TFIID subunit 1 [1381-1497]
Synonyms:
BA2R | CCG1 | CCGS | TAF1 | TAF1-BD1 | TAF1-BD1 (aa 1381-1497) | TAF1_HUMAN | TAF2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25344.81
Organism:
Homo sapiens (human)
Description:
P21675[1381-1497]
Residue:
217
Sequence:
PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIV
  
Inhibitor
Name:
BDBM346460
Synonyms:
US10202378, Example 73 | US10202378, Example 91a | US10202378, Example 91b | ethyl 2,6-dimethyl-7-oxo-4-(4,4,4-trifluoro-3-hydroxy-3-phenyl-but-1-ynyl)-1H-pyrrolo[2,3-c]pyridine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H19F3N2O4
Mol. Mass.:
432.3925
SMILES:
CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1ccccc1)C(F)(F)F
Structure:
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