Reaction Details Report a problem with these data
Target
Transcription initiation factor TFIID subunit 1 [1504-1635]
Ligand
BDBM346476
Substrate
n/a
Meas. Tech.
AF1-BD2 TR-FRET Binding Assay
IC50
21.4±n/a nM
Citation
 Adler, M; Burdick, DJ; Crawford, T; Duplessis, M; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Tsui, VH; Wang, S Therapeutic compounds and uses thereof US Patent  US10202378 Publication Date 2/12/2019 
Target
Name:
Transcription initiation factor TFIID subunit 1 [1504-1635]
Synonyms:
BA2R | CCG1 | CCGS | TAF1 | TAF1-BD2 (11 1504-1635) | TAF1-BD2 (aa 1504-1635) | TAF1_HUMAN | TAF2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15296.09
Organism:
Homo sapiens (Human)
Description:
P21675[1504-1635]
Residue:
132
Sequence:
QVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLD
  
Inhibitor
Name:
BDBM346476
Synonyms:
US10202378, Example 89 | US10202378, Example 93a | US10202378, Example 93b | ethyl 4-(4,4-difluoro-3-hydroxy-3-phenyl-but-1-ynyl)-2,6-dimethyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H20F2N2O4
Mol. Mass.:
414.402
SMILES:
CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(C(F)F)c1ccccc1
Structure:
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