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Target
Transcription initiation factor TFIID subunit 1 [1504-1635]
Ligand
BDBM346492
Substrate
n/a
Meas. Tech.
AF1-BD2 TR-FRET Binding Assay
IC50
33.9±n/a nM
Citation
 Adler, M; Burdick, DJ; Crawford, T; Duplessis, M; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Tsui, VH; Wang, S Therapeutic compounds and uses thereof US Patent  US10202378 Publication Date 2/12/2019 
Target
Name:
Transcription initiation factor TFIID subunit 1 [1504-1635]
Synonyms:
BA2R | CCG1 | CCGS | TAF1 | TAF1-BD2 (11 1504-1635) | TAF1-BD2 (aa 1504-1635) | TAF1_HUMAN | TAF2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15296.09
Organism:
Homo sapiens (Human)
Description:
P21675[1504-1635]
Residue:
132
Sequence:
QVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLD
  
Inhibitor
Name:
BDBM346492
Synonyms:
3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-2,6-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-one | US10202378, Example 187 | US10202378, Example 98a | US10202378, Example 98b
Type:
Small organic molecule
Emp. Form.:
C22H26N4O3
Mol. Mass.:
394.4668
SMILES:
Cc1[nH]c2c(c1-c1nnc(o1)C(C)(C)C)c(cn(C)c2=O)C#CC(C)(O)C1CC1
Structure:
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