Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM360794
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Pais, G; Hashimoto, A; Gadhachanda, VR; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS Alkyne compounds for treatment of complement mediated disorders US Patent US9828396 Publication Date 11/28/2017
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM360794
Synonyms:
1-(2-((1R,3S,5R)-3-(6- bromopyridin-2- ylcarbamoyl)-2- azabicyclo[3.1.0]hexan-2- yl)-2-oxoethyl)-5-((5- fluoropyrimidin-2- yl)ethynyl)-1H-indazole-3- carboxamide | US9828396, Compound 43
Type:
Small organic molecule
Emp. Form.:
C27H20BrFN8O3
Mol. Mass.:
603.402
SMILES:
NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)C#Cc1ncc(F)cn1 |r|