Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM360795
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Pais, G; Hashimoto, A; Gadhachanda, VR; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS Alkyne compounds for treatment of complement mediated disorders US Patent  US9828396 Publication Date 11/28/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM360795
Synonyms:
1-(2-((2S,4R)-2-(3,3- dimethylcyclohexylcarbamoyl)- 4-fluoropyrrolidin-1-yl)- 2-oxoethyl)-5-(pyrimidin-2- ylethynyl)-1H-indazole-3- carboxamide | US9828396, Compound 44
Type:
Small organic molecule
Emp. Form.:
C29H32FN7O3
Mol. Mass.:
545.6079
SMILES:
CC1(C)CCCC(C1)NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C(N)=O)c2cc(ccc12)C#Cc1ncccn1 |r,w:8.8|
Structure:
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