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Target
Histone acetyltransferase KAT2B
Ligand
BDBM371565
Substrate
n/a
Meas. Tech.
PCAF AlphaLisa Binding Assay
IC50
386±n/a nM
Citation
 Albrecht, BK; Burdick, DJ; Cote, A; Duplessis, M; Nasveschuk, CG; Taylor, AM Therapeutic compounds and uses thereof US Patent  US10239861 Publication Date 3/26/2019 
Target
Name:
Histone acetyltransferase KAT2B
Synonyms:
Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF
Type:
PROTEIN
Mol. Mass.:
93045.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502838
Residue:
832
Sequence:
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
  
Inhibitor
Name:
BDBM371565
Synonyms:
4-chloro-5-[[1-[(4-imidazol-1-ylphenyl)methyl]-3-piperidyl]amino]-2-methyl-pyridazin-3-one | US10239861, Example 45
Type:
Small organic molecule
Emp. Form.:
C20H23ClN6O
Mol. Mass.:
398.889
SMILES:
Cn1ncc(NC2CCCN(Cc3ccc(cc3)-n3ccnc3)C2)c(Cl)c1=O
Structure:
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