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Target
Indoleamine 2,3-dioxygenase 2
Ligand
BDBM387592
Substrate
n/a
Meas. Tech.
In-vitro IDO2 Enzyme (Indoleamine 2,3-dioxygenase2) Assay
IC50
<1000±n/a nM
Citation
 Banerjee, M; Middya, S; Shrivastava, R; Raina, S; Surya, A; Yadav, DB; Yadav, VK; Kapoor, KK; Venkatesan, A; Smith, RA; Thompson, SK Inhibitors of the kynurenine pathway US Patent  US10294212 Publication Date 5/21/2019 
Target
Name:
Indoleamine 2,3-dioxygenase 2
Synonyms:
I23O2_HUMAN | IDO-2 | IDO2 | INDOL1 | Indoleamine 2,3-dioxygenase-like protein 1 | Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Type:
PROTEIN
Mol. Mass.:
47079.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109909
Residue:
420
Sequence:
MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
  
Inhibitor
Name:
BDBM387592
Synonyms:
N3-(3,4- difluoro- phenyl)-7- (pyridin-4- yl)furo[2,3- c]pyridine-2,3- diamine | US10294212, No. 184
Type:
Small organic molecule
Emp. Form.:
C18H12F2N4O
Mol. Mass.:
338.3109
SMILES:
Nc1oc2c(nccc2c1Nc1ccc(F)c(F)c1)-c1ccncc1
Structure:
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