Reaction Details Report a problem with these data
Target
Gastric inhibitory polypeptide receptor
Ligand
BDBM29107
Substrate
125I-GIP
Meas. Tech.
SPA Receptor Binding Assay
IC50
368±n/a nM
Citation
Madsen, P; Kodra, JT; Behrens, C; Nishimura, E; Jeppesen, CB; Pridal, L; Andersen, B; Knudsen, LB; Valcarce-Aspegren, C; Guldbrandt, M; Christensen, IT; Jørgensen, AS; Ynddal, L; Brand, CL; Bagger, MA; Lau, J Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties. J Med Chem 52:2989-3000 (2009) [PubMed] Article
More Info.:
Target
Name:
Gastric inhibitory polypeptide receptor
Synonyms:
GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor
Type:
PROTEIN
Mol. Mass.:
53173.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1518286
Residue:
466
Sequence:
MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
Inhibitor
Name:
BDBM29107
Synonyms:
aminothiazole, 4
Type:
Small organic molecule
Emp. Form.:
C33H30F3N3O3S
Mol. Mass.:
605.67
SMILES:
OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1 |t:38|
Substrate
Name:
125I-GIP
Synonyms:
125I-Gastric inhibitory polypeptide | 125I-Glucose-dependent insulinotropic polypeptide
Type:
radiolabeled peptide substrate
Mol. Mass.:
4977.06
Organism:
Sus scrofa (Pig)
Description:
n/a
Residue:
42
Sequence:
YAEGTFISDYSIAMDKIRQQDFVNWLLAQKGKKSDWKHNITQ