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Target
Peptidyl-prolyl cis-trans isomerase D
Ligand
BDBM394274
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
<10000±n/a nM
Citation
 Jorand-Lebrun, C; Johnson, TL; Graedler, U; Jiang, X; Kulkarni, S Compounds for the inhibition of cyclophilins and uses thereof US Patent  US9975902 Publication Date 5/22/2018 
Target
Name:
Peptidyl-prolyl cis-trans isomerase D
Synonyms:
40 kDa peptidyl-prolyl cis-trans isomerase | CYP-40 | CYP40 | CYPD | Cyclophilin D (CypD) | Cyclophilin-40 | Cyclophilin-related protein | PPID | PPID_HUMAN | PPIase D | Peptidyl-prolyl cis-trans isomerase D | Rotamase D
Type:
Protein
Mol. Mass.:
40766.62
Organism:
Homo sapiens (Human)
Description:
Q08752
Residue:
370
Sequence:
MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA
  
Inhibitor
Name:
BDBM394274
Synonyms:
US9975902, Example 4
Type:
Small organic molecule
Emp. Form.:
C18H19N3O5
Mol. Mass.:
357.3606
SMILES:
[O-][N+](=O)c1ccc(CNC(=O)CN2C(=O)C3[C@@H]4CCC(C4)[C@@H]3C2=O)cc1 |r|
Structure:
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