Reaction Details Report a problem with these data
Target
Potassium-transporting ATPase alpha chain 1
Ligand
BDBM394382
Substrate
n/a
Meas. Tech.
Proton Potassium-adenosine Triphosphatase (H+,K+-ATPase) Inhibitory Activity
IC50
710±n/a nM
Citation
 Kajino, M; Hasuoka, A; Tarui, N; Takagi, T Proton pump inhibitors US Patent  US10308605 Publication Date 6/4/2019 
Target
Name:
Potassium-transporting ATPase alpha chain 1
Synonyms:
ATP4A | ATP4A_PIG | Gastric H(+)/K(+) ATPase subunit alpha | H+/K+-ATPase | Na/K-ATPase | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump
Type:
Enzyme
Mol. Mass.:
114279.23
Organism:
Sus scrofa (Pig)
Description:
P19156
Residue:
1034
Sequence:
MGKAENYELYQVELGPGPSGDMAAKMSKKKAGRGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY
  
Inhibitor
Name:
BDBM394382
Synonyms:
1-[(4-Methoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde | US10308605, Example 12
Type:
Small organic molecule
Emp. Form.:
C18H15NO4S
Mol. Mass.:
341.381
SMILES:
COc1ccc(cc1)S(=O)(=O)n1cc(C=O)cc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: