Reaction Details Report a problem with these data
Target
Transcription activator BRG1 [1448-1575]
Ligand
BDBM394399
Substrate
n/a
Meas. Tech.
BRG1 TR-FRET Binding Assay
IC50
21.4±n/a nM
Citation
 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Therapeutic compounds and uses thereof US Patent  US10308614 Publication Date 6/4/2019 
Target
Name:
Transcription activator BRG1 [1448-1575]
Synonyms:
ATP-dependent helicase SMARCA4 | BAF190A | BRG1 | His-BRG1 (A1448-S1575) | SMARCA4 | SMCA4_HUMAN | SNF2B | SNF2L4 | Transcription activator BRG1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14937.42
Organism:
Homo sapiens (Human)
Description:
P51532(A1448-S1575)
Residue:
128
Sequence:
AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES
  
Inhibitor
Name:
BDBM394399
Synonyms:
US10308614, Example 1 | tert-butyl 4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C19H25N5O3
Mol. Mass.:
371.4335
SMILES:
CC(C)(C)OC(=O)N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O
Structure:
Search PDB for entries with ligand similarity: