Reaction Details Report a problem with these data
Target
D-aspartate oxidase
Ligand
BDBM31172
Substrate
BDBM31174
Meas. Tech.
DAAO in Vitro Activity Assay
IC50
>43200±n/a nM
Citation
Duplantier, AJ; Becker, SL; Bohanon, MJ; Borzilleri, KA; Chrunyk, BA; Downs, JT; Hu, LY; El-Kattan, A; James, LC; Liu, S; Lu, J; Maklad, N; Mansour, MN; Mente, S; Piotrowski, MA; Sakya, SM; Sheehan, S; Steyn, SJ; Strick, CA; Williams, VA; Zhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem 52:3576-85 (2009) [PubMed] Article
More Info.:
Target
Name:
D-aspartate oxidase
Synonyms:
D-Aspartate Oxidase (DDO) | DASOX | DDO | OXDD_HUMAN
Type:
Oxidoreductase
Mol. Mass.:
37543.06
Organism:
Human
Description:
Recombinant human DDO expressed and purified from sf9 insect cells, was used in enzyme assays.
Residue:
341
Sequence:
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
Inhibitor
Name:
BDBM31172
Synonyms:
3-hydroxyquinolin-2(1H)-one, 26
Type:
Small organic molecule
Emp. Form.:
C9H5ClFNO2
Mol. Mass.:
213.593
SMILES:
Oc1cc2c(Cl)c(F)ccc2[nH]c1=O