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Target
DNA polymerase beta
Ligand
BDBM33384
Substrate
DNA template-primer
Meas. Tech.
DNA Polymerase Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
64000±n/a nM
Citation
 Kuramochi, K; Fukudome, K; Kuriyama, I; Takeuchi, T; Sato, Y; Kamisuki, S; Tsubaki, K; Sugawara, F; Yoshida, H; Mizushina, Y Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors. Bioorg Med Chem 17:7227-38 (2009) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
  
Inhibitor
Name:
BDBM33384
Synonyms:
dehydroaltenusin
Type:
Small organic molecule
Emp. Form.:
C15H12O6
Mol. Mass.:
288.2522
SMILES:
COc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1 |c:17|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
DNA template-primer
Synonyms:
poly(dA)/oligo(dT)(12Â?1), A/T = 2/1
Type:
Duplex DNA
Mol. Mass.:
358.43
Organism:
n/a
Description:
[3H]-dTTP as co-substrate.
Residue:
3
Sequence:
NA