Reaction Details Report a problem with these data
Target
DNA polymerase beta
Ligand
BDBM33389
Substrate
DNA template-primer
Meas. Tech.
DNA Polymerase Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
89000±n/a nM
Citation
 Kuramochi, K; Fukudome, K; Kuriyama, I; Takeuchi, T; Sato, Y; Kamisuki, S; Tsubaki, K; Sugawara, F; Yoshida, H; Mizushina, Y Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors. Bioorg Med Chem 17:7227-38 (2009) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
  
Inhibitor
Name:
BDBM33389
Synonyms:
dehydroaltenusin derivative, 20
Type:
Small organic molecule
Emp. Form.:
C14H10O5
Mol. Mass.:
258.2262
SMILES:
CC12CC(=O)C(=O)C=C1c1cccc(O)c1C(=O)O2 |c:7|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
DNA template-primer
Synonyms:
poly(dA)/oligo(dT)(12Â?1), A/T = 2/1
Type:
Duplex DNA
Mol. Mass.:
358.43
Organism:
n/a
Description:
[3H]-dTTP as co-substrate.
Residue:
3
Sequence:
NA