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Target
DNA polymerase beta
Ligand
BDBM33392
Substrate
DNA template-primer
Meas. Tech.
DNA Polymerase Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
>200000±n/a nM
Citation
Kuramochi, K; Fukudome, K; Kuriyama, I; Takeuchi, T; Sato, Y; Kamisuki, S; Tsubaki, K; Sugawara, F; Yoshida, H; Mizushina, Y Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors. Bioorg Med Chem 17:7227-38 (2009) [PubMed] Article
More Info.:
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rat
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
Inhibitor
Name:
BDBM33392
Synonyms:
dehydroaltenusin derivative, 31
Type:
Small organic molecule
Emp. Form.:
C15H12O5
Mol. Mass.:
272.2528
SMILES:
COc1cc(O)c2C(=O)OC3(C)C=CC(=O)C=C3c2c1 |c:12,16|
Substrate
Name:
DNA template-primer
Synonyms:
poly(dA)/oligo(dT)(12-1), A/T = 2/1
Type:
Duplex DNA
Mol. Mass.:
18.02
Organism:
n/a
Description:
[3H]-dTTP as co-substrate.
Residue:
0
Sequence:
NA