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Target
Hexokinase-4
Ligand
BDBM34088
Substrate
BDBM34103
Meas. Tech.
Glycogen Phosphorylase Enzyme Assay
Citation
 Zhang, L; Li, H; Zhu, Q; Liu, J; Chen, L; Leng, Y; Jiang, H; Liu, H Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase. Bioorg Med Chem 17:7301-12 (2009) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM34088
Synonyms:
benzamide derivative, 13p
Type:
Small organic molecule
Emp. Form.:
C20H16FN5OS
Mol. Mass.:
393.437
SMILES:
Cc1cc(C)nc(Sc2cc(C(=O)Nc3cccc(c3)C#N)c(N)cc2F)n1
Structure:
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Substrate
Name:
BDBM34103
Synonyms:
D-glucose | dextrose | glucose
Type:
n/a
Emp. Form.:
C6H12O6
Mol. Mass.:
180.1559
SMILES:
OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O
Structure:
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