Reaction Details Report a problem with these data
Target
Adenosylhomocysteine nucleosidase
Ligand
BDBM50170093
Substrate
BDBM22111
Meas. Tech.
Enzyme Activity Assay
pH
7.5±0
Temperature
298.15±0 K
Kd
1.2±0.0 nM
Citation
Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol 2:725-34 (2007) [PubMed] Article
More Info.:
Target
Name:
Adenosylhomocysteine nucleosidase
Synonyms:
5'-methylthioadenosine nucleosidase | MTN | Methylthioadenosine Nucleosidase (MTAN)
Type:
Enzyme
Mol. Mass.:
25233.34
Organism:
Helicobacter pylori
Description:
D0IQW9
Residue:
231
Sequence:
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHDKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLNKDLKINDLLVAIQLVQHDVDLSAFNHPLGFIPESAIFIETSESLNALAKKVANEQHITLKEGVIASGDQFVHSKERKEFLISEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDKL
Inhibitor
Name:
BDBM50170093
Synonyms:
2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-methylsulfanylmethyl-pyrrolidinium | ImmA-Me
Type:
Small organic molecule
Emp. Form.:
C12H18N5O2S
Mol. Mass.:
296.368
SMILES:
CSCC1[NH2+]C(C(O)C1O)c1c[nH]c2c(N)ncnc12
Substrate
Name:
BDBM22111
Synonyms:
(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | 5'-Methylthioado | 5-methylthioadenosine | CHEMBL277041 | MTA
Type:
Nucleoside or nucleotide
Emp. Form.:
C11H15N5O3S
Mol. Mass.:
297.334
SMILES:
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12