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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
Ligand
BDBM47379
Substrate
n/a
Meas. Tech.
Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen
EC50
1210±n/a nM
Citation
 PubChem, PC Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen PubChem Bioassay (2009)[AID] 
Target
Name:
Broad substrate specificity ATP-binding cassette transporter ABCG2
Synonyms:
ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter
Type:
Multi-pass membrane protein; monomer or homodimer; disulfide-linked
Mol. Mass.:
72329.48
Organism:
Homo sapiens (Human)
Description:
Q9UNQ0
Residue:
655
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
  
Inhibitor
Name:
BDBM47379
Synonyms:
N-[5-(dimethylamino)-2-[4-morpholinyl-[3-(trifluoromethyl)anilino]phosphoryl]phenyl]-2-thiophenecarboxamide | N-[5-(dimethylamino)-2-[morpholin-4-yl-[3-(trifluoromethyl)anilino]phosphoryl]phenyl]thiophene-2-carboxamide | N-[5-(dimethylamino)-2-[morpholin-4-yl-[[3-(trifluoromethyl)phenyl]amino]phosphoryl]phenyl]thiophene-2-carboxamide | N-[5-(dimethylamino)-2-[morpholino-[3-(trifluoromethyl)anilino]phosphoryl]phenyl]thiophene-2-carboxamide | UNM000011097001 | cid_2320400
Type:
Small organic molecule
Emp. Form.:
C24H26F3N4O3PS
Mol. Mass.:
538.522
SMILES:
CN(C)c1ccc(c(NC(=O)c2cccs2)c1)P(=O)(Nc1cccc(c1)C(F)(F)F)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: