Reaction Details Report a problem with these data
Target
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Ligand
BDBM267784
Substrate
n/a
Meas. Tech.
Fluorescence based hOGA assay
pH
7.0000±n/a
Temperature
298.1500±n/a K
Ki
9.90±n/a nM
Comments
extracted
Citation
 Kaul, R; McEachern, EJ; Vocadlo, DJ; Zhou, Y; Liu, K; Selnick, HG; Wei, Z; Mu, C; Wang, Y; Wang, X Selective glycosidase inhibitors and uses thereof US Patent  US9718854 Publication Date 8/1/2017 
Target
Name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Synonyms:
Dihydrodipicolinate synthase-like, mitochondrial | DHDPS-like protein | 2-keto-4-hydroxyglutarate aldolase | Probable KHG-aldolase | Protein 569272 | HOGA1_HUMAN | HOGA1 | C10orf65 | DHDPSL | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
35253.21
Organism:
Human
Description:
ChEMBL_461876
Residue:
327
Sequence:
MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPVDAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVCALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGGPCRAPLQELSPAEEEALRMDFTSNGWL
  
Inhibitor
Name:
BDBM267784
Synonyms:
((3aR,5R,6S,7R,7aR)-6,7-dihydroxy- 2-(methylamino)-5,6,7,7a-tetrahydro- 3aH-pyrano[3,2-d]thiazol-5-yl)methyl dimethylcarbamate | US9718854, 9
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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