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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50240229
Substrate
n/a
Meas. Tech.
ChEMBL_1667830 (CHEMBL4017718)
Ki
38±n/a nM
Citation
 Salvino, JM; Srikanth, YVV; Lou, R; Oyer, HM; Chen, N; Kim, FJ Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer. Bioorg Med Chem Lett 27:2216-2220 (2017) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50240229
Synonyms:
CHEMBL4084182
Type:
Small organic molecule
Emp. Form.:
C16H17ClFN3O
Mol. Mass.:
321.777
SMILES:
Fc1ccc(OCCCNC(=N)Nc2ccc(Cl)cc2)cc1
Structure:
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