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Target
Leucine--tRNA ligase, cytoplasmic
Ligand
BDBM50241780
Substrate
n/a
Meas. Tech.
ChEMBL_1670428 (CHEMBL4020316)
EC50
82800±n/a nM
Citation
 Li, X; Hernandez, V; Rock, FL; Choi, W; Mak, YSL; Mohan, M; Mao, W; Zhou, Y; Easom, EE; Plattner, JJ; Zou, W; Pérez-Herrán, E; Giordano, I; Mendoza-Losana, A; Alemparte, C; Rullas, J; Angulo-Barturen, I; Crouch, S; Ortega, F; Barros, D; Alley, MRK Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem 60:8011-8026 (2017) [PubMed]  Article 
Target
Name:
Leucine--tRNA ligase, cytoplasmic
Synonyms:
KIAA1352 | LARS | LARS1 | Leucyl-tRNA synthetase | SYLC_HUMAN
Type:
PROTEIN
Mol. Mass.:
134475.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_98544
Residue:
1176
Sequence:
MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
  
Inhibitor
Name:
BDBM50241780
Synonyms:
CHEMBL4105269
Type:
Small organic molecule
Emp. Form.:
C10H12BCl2NO4
Mol. Mass.:
291.924
SMILES:
Cl.NC[C@H]1OB(O)c2c1c(Cl)cc1OCCOc21 |r|
Structure:
Search PDB for entries with ligand similarity: