Reaction Details Report a problem with these data
Target
G-protein coupled receptor 84
Ligand
BDBM50245482
Substrate
n/a
Meas. Tech.
ChEMBL_1674753 (CHEMBL4024896)
IC50
10.0±n/a nM
Citation
 Liu, YM; Nepali, K; Liou, JP Idiopathic Pulmonary Fibrosis: Current Status, Recent Progress, and Emerging Targets. J Med Chem 60:527-553 (2017) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 84
Synonyms:
EX33 | G-protein coupled receptor 84 | GPR84 | GPR84_HUMAN | Inflammation-related G-protein coupled receptor EX33
Type:
PROTEIN
Mol. Mass.:
43726.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116040
Residue:
396
Sequence:
MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
  
Inhibitor
Name:
BDBM50245482
Synonyms:
CHEMBL4069275
Type:
Small organic molecule
Emp. Form.:
C27H26N4O5
Mol. Mass.:
486.5191
SMILES:
Cc1cc(COc2ccc-3c(CCn4c-3cc(OCC3COc5ncccc5O3)cc4=O)c2)nn1C
Structure:
Search PDB for entries with ligand similarity: