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Target
Histone deacetylase 8
Ligand
BDBM50397360
Substrate
n/a
Meas. Tech.
ChEMBL_1677037 (CHEMBL4027180)
IC50
92±n/a nM
Citation
 Heimburg, T; Kolbinger, FR; Zeyen, P; Ghazy, E; Herp, D; Schmidtkunz, K; Melesina, J; Shaik, TB; Erdmann, F; Schmidt, M; Romier, C; Robaa, D; Witt, O; Oehme, I; Jung, M; Sippl, W Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity. J Med Chem 60:10188-10204 (2017) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50397360
Synonyms:
CHEMBL2170177 | US10188756, Compound CN110
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3
Mol. Mass.:
296.3205
SMILES:
COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1
Structure:
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