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Target
Platelet-activating factor receptor
Ligand
BDBM50007472
Substrate
n/a
Meas. Tech.
ChEBML_86450
IC50
>50000±n/a nM
Citation
 Piwinski, JJ; Wong, JK; Green, MJ; Ganguly, AK; Billah, MM; West, RE; Kreutner, W Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. J Med Chem 34:457-61 (1991) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50007472
Synonyms:
1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexyl]-ethanone | CHEMBL341584
Type:
Small organic molecule
Emp. Form.:
C22H22ClNO
Mol. Mass.:
351.869
SMILES:
CC(=O)C1CCC(CC1)=C1c2ccc(Cl)cc2CCc2cccnc12 |(9.33,-15.2,;8.01,-14.43,;6.66,-15.18,;8.01,-12.89,;9.36,-12.16,;9.4,-10.62,;8.08,-9.84,;6.75,-10.57,;6.72,-12.09,;8.11,-8.3,;9.61,-7.63,;10.74,-8.72,;12.26,-8.29,;12.61,-6.76,;14.11,-6.34,;11.48,-5.67,;9.99,-6.12,;9.09,-5.01,;7.55,-5.01,;6.47,-6.11,;5.02,-5.62,;3.89,-6.62,;4.18,-8.13,;5.62,-8.62,;6.78,-7.62,)|
Structure:
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