Reaction Details Report a problem with these data
Target
Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3
Ligand
BDBM50257064
Substrate
n/a
Meas. Tech.
ChEBML_1688712
IC50
>100000±n/a nM
Citation
 Felts, AS; Rodriguez, AL; Blobaum, AL; Morrison, RD; Bates, BS; Thompson Gray, A; Rook, JM; Tantawy, MN; Byers, FW; Chang, S; Venable, DF; Luscombe, VB; Tamagnan, GD; Niswender, CM; Daniels, JS; Jones, CK; Conn, PJ; Lindsley, CW; Emmitte, KA Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. J Med Chem 60:5072-5085 (2017) [PubMed]  Article 
Target
Name:
Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1688712
Components:
This complex has 2 components.
Component 1
Name:
Potassium voltage-gated channel subfamily D member 3
Synonyms:
KCND3 | KCND3_HUMAN | Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3 | Potassium voltage-gated channel subfamily D member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv4.3
Type:
PROTEIN
Mol. Mass.:
73464.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1478652
Residue:
655
Sequence:
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
  
Component 2
Name:
Kv channel-interacting protein 2
Synonyms:
A-type potassium channel modulatory protein 2 | Cardiac voltage-gated potassium channel modulatory subunit | KCHIP2 | KCIP2_HUMAN | KCNIP2 | Kv channel-interacting protein 2 | Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3 | Potassium channel-interacting protein 2
Type:
PROTEIN
Mol. Mass.:
30896.89
Organism:
Homo sapiens
Description:
ChEMBL_117142
Residue:
270
Sequence:
MRGQGRKESLSDSRDLDGSYDQLTGHPPGPTKKALKQRFLKLLPCCGPQALPSVSETLAAPASLRPHRPRLLDPDSVDDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTVDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQKDENIMRSMQLFDNVI
  
Inhibitor
Name:
BDBM50257064
Synonyms:
CHEMBL2386850
Type:
Small organic molecule
Emp. Form.:
C16H12FN5O2
Mol. Mass.:
325.2972
SMILES:
Cc1cc(Oc2cncnc2)cc(n1)C(=O)Nc1ccc(F)cn1
Structure:
Search PDB for entries with ligand similarity: