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Target
Alpha-galactosidase A
Ligand
BDBM50290906
Substrate
n/a
Meas. Tech.
ChEMBL_1730813 (CHEMBL4146349)
IC50
13000±n/a nM
Citation
 Li, HY; Lee, JD; Chen, CW; Sun, YC; Cheng, WC Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines. Eur J Med Chem 144:626-634 (2018) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM50290906
Synonyms:
CHEMBL4165270
Type:
Small organic molecule
Emp. Form.:
C16H30N2O4
Mol. Mass.:
314.4204
SMILES:
[#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])-[#6]-[#6](=O)-[#7]-[#6]-[#6@H]-1-[#7]-[#6]-[#6@H](-[#8])-[#6@@H](-[#8])-[#6@H]-1-[#8] |r|
Structure:
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