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Found 47 with Last Name = 'cheng' and Initial = 'wc'
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324676((R)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosp...)
Affinity DataKi:  18nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of SEW2871-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438750(CHEMBL2414884)
Affinity DataKi:  71nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324676((R)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosp...)
Affinity DataKi:  77nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of S1P-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438754(CHEMBL2414880)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438752(CHEMBL2414882)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438753(CHEMBL2414881)
Affinity DataKi:  1.00E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438748(CHEMBL2414879)
Affinity DataKi:  1.10E+3nMAssay Description:Non-competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM18358((2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-...)
Affinity DataKi:  1.30E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM50375511(CHEMBL406973)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of recombinant human lysosomal alpha-glucosidase assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234559(CHEMBL4081664)
Affinity DataKi:  2.00E+3nMAssay Description:Non-competitive inhibition of recombinant human alpha GAL-A using varying levels of 4-methylumbelliferyl alpha-D-galactopyranoside substrate at pH 7 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324677((S)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosp...)
Affinity DataKi:  2.84E+3nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of SEW2871-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438751(CHEMBL2414883)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50290908(CHEMBL4160428)
Affinity DataKi:  3.50E+3nMAssay Description:Competitive inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by Lineweaver-Burk plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50438749(CHEMBL2414888)
Affinity DataKi:  4.10E+3nMAssay Description:Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324677((S)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosp...)
Affinity DataKi:  4.63E+3nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of S1P-induced [35S]GTPgamma bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM50375510(CHEMBL405957)
Affinity DataKi:  6.40E+3nMAssay Description:Competitive inhibition of recombinant human lysosomal alpha-glucosidase assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234559(CHEMBL4081664)
Affinity DataKi:  7.70E+3nMAssay Description:Non-competitive inhibition of recombinant human alpha GAL-A using varying levels of 4-methylumbelliferyl alpha-D-galactopyranoside substrate at pH 4....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataKi:  1.15E+5nMAssay Description:Competitive inhibition of recombinant human lysosomal alpha-glucosidase assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50099009((3S,4S,5R)-2-Aminomethyl-5-hydroxymethyl-pyrrolidi...)
Affinity DataIC50:  53nMpH: 7.0Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50099009((3S,4S,5R)-2-Aminomethyl-5-hydroxymethyl-pyrrolidi...)
Affinity DataIC50:  670nMpH: 4.6Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 4.6 after 10 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50:  750nMpH: 7.0Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50:  750nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50:  1.00E+3nMpH: 4.6Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 4.6 after 10 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234560(CHEMBL4069007)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50290904(CHEMBL4168689)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234559(CHEMBL4081664)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234561(CHEMBL4090087)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50290907(CHEMBL4175528)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50290905(CHEMBL4173174)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50290903(CHEMBL4176543)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234560(CHEMBL4069007)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234563(CHEMBL4072729)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50204611(CHEMBL1289018 | D-15)
Affinity DataIC50:  9.50E+3nMpH: 7.0Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234559(CHEMBL4081664)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50204610(CHEMBL3908900)
Affinity DataIC50:  1.06E+4nMpH: 7.0Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234565(CHEMBL4093453)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50290906(CHEMBL4165270)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50204609(CHEMBL3985941)
Affinity DataIC50:  1.40E+4nMpH: 7.0Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234565(CHEMBL4093453)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50204613(CHEMBL3929052)
Affinity DataIC50:  2.21E+4nMpH: 7.0Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234563(CHEMBL4072729)
Affinity DataIC50:  3.04E+4nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50234561(CHEMBL4090087)
Affinity DataIC50:  3.28E+4nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50204610(CHEMBL3908900)
Affinity DataIC50:  3.42E+4nMpH: 4.6Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 4.6 after 10 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50204609(CHEMBL3985941)
Affinity DataIC50:  2.66E+5nMpH: 4.6Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 4.6 after 10 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed