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Target
Alpha-galactosidase A
Ligand
BDBM50234561
Substrate
n/a
Meas. Tech.
ChEMBL_1653300 (CHEMBL4002666)
IC50
3000±n/a nM
Citation
 Cheng, WC; Wang, JH; Yun, WY; Li, HY; Hu, JM Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease. Eur J Med Chem 126:1-6 (2017) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM50234561
Synonyms:
CHEMBL4090087
Type:
Small organic molecule
Emp. Form.:
C16H21BrN2O5
Mol. Mass.:
401.252
SMILES:
COc1ccc(Br)cc1\C=C\C(=O)NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O |r|
Structure:
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