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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50291368
Substrate
n/a
Meas. Tech.
ChEMBL_1731036 (CHEMBL4146572)
IC50
2800±n/a nM
Citation
 Saraswati, AP; Ali Hussaini, SM; Krishna, NH; Babu, BN; Kamal, A Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions. Eur J Med Chem 144:843-858 (2018) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3
Type:
PROTEIN
Mol. Mass.:
46774.42
Organism:
Sus scrofa
Description:
ChEMBL_939732
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
  
Inhibitor
Name:
BDBM50291368
Synonyms:
CHEMBL4167852
Type:
Small organic molecule
Emp. Form.:
C27H26N4O5S
Mol. Mass.:
518.584
SMILES:
CCOC(=O)c1c2[S+]([O-])NC(=O)c2c(-c2ccc(NC(=O)CCN(C)C)cc2)c2c3ccccc3[nH]c12
Structure:
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