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Found 176 with Last Name = 'saraswati' and Initial = 'ap'
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM8349(6-aryl-pyrazolo[3,4-b]pyridine analogue 13 | CHEMB...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM8350(6-aryl-pyrazolo[3,4-b]pyridine analogue 14 | N-[5-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50291344(CHEMBL4165510)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50291367(CHEMBL4164416)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50291346(CHEMBL4162850)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50291345(CHEMBL4169204)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM139295(US10858323, Compound 1 | US8614223, 73)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50291366(CHEMBL4172295)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50252391(CHEMBL4080014)
Affinity DataIC50:  3nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50505365(Obp-801 | YM-753)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50591852(CHEMBL5188540)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of HADC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50291370(CHEMBL4172418)
Affinity DataIC50:  4nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM8579(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 24 | N-[6-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human GSK3beta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM8310(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}cyclope...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50291365(CHEMBL4161007)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of recombinant GSK3-beta (unknown origin) assessed as decrease in phosphorylation of CREB at serine-129 in presence of ATP[gamma-33P] by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  6nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50219330(CHEMBL303926)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human GSK3alpha using biotin-Ahx-AAAKRREILSRRP-S(PO3)YR-amide as substrate after 40 mins in presence of [33gammaP]-ATP by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50562487(CHEMBL4757504)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50147458((3-{3-[4-(2-Methoxy-phenyl)-2,5-dioxo-2,5-dihydro-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM139323(US8614223, 101)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50562491(CHEMBL4744710)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50: <15nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  15nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50: <15nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50: <15nMAssay Description:Inhibition of HADC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50591853(CHEMBL5176595)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  20nMAssay Description:Inhibition of HADC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50591850(CHEMBL5184498)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50147463(3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-4-[1-(...)
Affinity DataIC50:  26nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50562489(CHEMBL4750401)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50409064(CHEMBL5269954)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  30nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50562492(CHEMBL4752147)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50468978(CHEMBL4291778)
Affinity DataIC50:  42nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591850(CHEMBL5184498)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant human HDAC8 using FLUOR DE LYS as substrate preincubated for 15 mins followed by substrate addition measured after 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at alpha1A adrenoceptor in Wistar rat vas deferans assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50562490(CHEMBL4793901)
Affinity DataIC50:  45nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50562488(CHEMBL4787955)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)Lys-AMC as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50:  48nMAssay Description:Inhibition of HADC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50561897(CHEMBL4794313)
Affinity DataIC50:  49nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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