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Target
Myosin-2 heavy chain, non muscle
Ligand
BDBM50449472
Substrate
n/a
Meas. Tech.
ChEMBL_1739750 (CHEMBL4155500)
IC50
83000±n/a nM
Citation
 Roman, BI; Verhasselt, S; Stevens, CV Medicinal Chemistry and Use of Myosin II Inhibitor ( S)-Blebbistatin and Its Derivatives. J Med Chem 61:9410-9428 (2018) [PubMed]  Article 
Target
Name:
Myosin-2 heavy chain, non muscle
Synonyms:
MYSN_ACACA | Myosin II heavy chain, non muscle | Myosin-2 heavy chain, non muscle
Type:
PROTEIN
Mol. Mass.:
171184.61
Organism:
Acanthamoeba castellanii
Description:
ChEMBL_117944
Residue:
1509
Sequence:
MAAQRRRKGGEVESDYIKYLKYKNTGFQVSASDKTLAWWPTKDADRAFCHVEVTKDDGKNFTVRLENGEEKSQPKNEKNFLGVNPPKFDGVEDMGELGYLNEPAVLHNLKKRYDADLFHTYSGLFLVVVNPYKRLPVYTPEIIDIYRGRQRDKVAPHIFAISDAAYRAMLNTRQNQSMLITGESGAGKTENTKKVIQYLTAIAGRAEGGLLEQQLLEFNPILEAFGNAKTTKNNNSSRFGKFIELQFNAGGQITGANTFIYLLEKSRVTAQGAGERNFHIFYQILSKAMPEELKQKLKLTKPEDYFFLNQNACYTVDDMDDAKEFDHMLKAFDILNINEEERLAIFQTISAILHLGNLPFIDVNSETAGLKDEVELNIAAELLGVSAAGLKAGLLSPRIKAGNEWVTRALNKPKAMASRDALCKALFGRLFLWIVQKINRILSHKDKTALWIGVLDISGFEIFQHNSFEQLCINYTNEKLQQFFNHHMFTLEQQEYEREKIDWTFVDYGMDSQDCIDLIEKKPMGILPLLDEQTVFPDADDTSFTKKLFQTHENHRNFRRPRFDANNFKIVHYAGEVEYQTSAWLEKNRDPLEDDLSNLCKKSSVRFVTGLFDEDLMPSFKAAPAEEEKAAAGGSRNRSTGRGKGGAQFITVAFQYKEQLAHLMSMLSSTAPHFIRCIIPNLGKKPGVVSDQLVLDQLKCNGVLEGIRIARKGWPNRLKYDEFLKRYFLLKPGATPTSPSTKDAVKDLIEHLIAKEPTKVNKDEVRFGVTKIFFRSGQLAAIEELREQAISKMVVSIQAGARAFLARRMYDKMREQTVSAKILQRNIRAWLELKNWAWYQLYVKARPLISQRNFQKEIDDLKKQVKDLEKELAALKDANAKLDKEKQLAEEDADKLEKDLAALKLKILDLEGEKADLEEDNALLQKKVAGLEEELQEETSASNDILEQKRKLEAEKGELKASLEEEERNRKALQEAKTKVESERNELQDKYEDEAAAHDSLKKKEEDLSRELRETKDALADAENISETLRSKLKNTERGADDVRNELDDVTATKLQLEKTKKSLEEELAQTRAQLEEEKSGKEAASSKAKQLGQQLEDARSEVDSLKSKLSAAEKSLKTAKDQNRDLDEQLEDERTVRANVDKQKKALEAKLTELEDQVTALDGQKNAAAAQAKTLKTQVDETKRRLEEAEASAARLEKERKNALDEVAQLTADLDAERDSGAQQRRKLNTRISELQSELENAPKTGGASSEEVKRLEGELERLEEELLTAQEARAAAEKNLDKANLELEELRQEADDAARDNDKLVKDNRKLKADLDEARIQLEEEQDAKSHADSSSRRLLAEIEELKKRVAKETSDKQKAQDQKANYQRENESLKADRDSIERRNRDAERQVRDLRAQLDDALSRLDSEKRAKEKSVEANRELKKVVLDRERQSLESLSKFNSALESDKQILEDEIGDLHEKNKQLQAKIAQLQDEIDGTPSSRGGSTRGASARGASVRAGSARAEE
  
Inhibitor
Name:
BDBM50449472
Synonyms:
CHEBI:75379 | CHEMBL1328324
Type:
Small organic molecule
Emp. Form.:
C18H16N2O2
Mol. Mass.:
292.3318
SMILES:
Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c1ccccc1 |t:5|
Structure:
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