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Target
Fusion glycoprotein F0
Ligand
BDBM50450562
Substrate
n/a
Meas. Tech.
ChEMBL_1742867 (CHEMBL4158617)
IC50
2300±n/a nM
Citation
 Zheng, X; Liang, C; Wang, L; Wang, B; Liu, Y; Feng, S; Wu, JZ; Gao, L; Feng, L; Chen, L; Guo, T; Shen, HC; Yun, H Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors. J Med Chem 61:10228-10241 (2018) [PubMed]  Article 
Target
Name:
Fusion glycoprotein F0
Synonyms:
F | Fusion glycoprotein F0
Type:
PROTEIN
Mol. Mass.:
63485.30
Organism:
Human respiratory syncytial virus
Description:
ChEMBL_106144
Residue:
574
Sequence:
MELPILKANAITTILAAVTFCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLMKQELDKYKNAVTELQLLMQSTPAANNRARRELPRFMNYTLNNTKKTNVTLSKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCRISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
  
Inhibitor
Name:
BDBM50450562
Synonyms:
CHEMBL4162598
Type:
Small organic molecule
Emp. Form.:
C21H24N4
Mol. Mass.:
332.4421
SMILES:
NCCNc1cc(nc2ccccc12)N1CCCc2ccccc2C1
Structure:
Search PDB for entries with ligand similarity: