Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50451731
Substrate
n/a
Meas. Tech.
ChEMBL_1746132 (CHEMBL4180642)
IC50
7540±n/a nM
Citation
 Majekova, MBallekova, JPrnova, MStefek, M Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity. Bioorg Med Chem 25:6353-6360 (2017) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50451731
Synonyms:
CHEMBL4216153
Type:
Small organic molecule
Emp. Form.:
C17H18N2O3
Mol. Mass.:
298.3364
SMILES:
OC(=O)Cn1c2CCN(Cc2c2ccccc12)C(=O)C1CC1
Structure:
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