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Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM50453185
Substrate
n/a
Meas. Tech.
ChEMBL_1749251 (CHEMBL4183761)
IC50
3.0±n/a nM
Citation
 Gucký, T; ?ezní?ková, E; Rado?ová Muchová, T; Jorda, R; Klejová, Z; Malínková, V; Berka, K; Bazgier, V; Ajani, H; Lep?ík, M; Divoký, V; Kry?tof, V Discovery of N J Med Chem 61:3855-3869 (2018) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM50453185
Synonyms:
CHEMBL4203825
Type:
Small organic molecule
Emp. Form.:
C28H41N9
Mol. Mass.:
503.6854
SMILES:
CCN1CCN(CC1)c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3n(cnc23)C2CCCC2)cc1 |r,wU:17.17,wD:20.21,(51.74,-32.62,;50.97,-31.28,;49.43,-31.28,;48.66,-29.95,;47.12,-29.95,;46.35,-31.28,;47.12,-32.62,;48.66,-32.62,;44.81,-31.28,;44.04,-32.62,;42.5,-32.62,;41.73,-31.28,;40.19,-31.28,;39.42,-29.95,;40.19,-28.62,;39.42,-27.29,;40.19,-25.95,;41.73,-25.95,;42.5,-24.62,;44.04,-24.62,;44.81,-25.95,;46.35,-25.95,;44.04,-27.29,;42.5,-27.29,;37.88,-27.29,;37.11,-28.62,;35.6,-28.94,;35.44,-30.47,;36.85,-31.09,;37.88,-29.95,;34.46,-27.9,;32.95,-28.23,;32.18,-26.89,;33.22,-25.75,;34.62,-26.37,;42.5,-29.95,;44.04,-29.95,)|
Structure:
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