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Target
Reverse transcriptase
Ligand
BDBM50454272
Substrate
n/a
Meas. Tech.
ChEMBL_1752565 (CHEMBL4187325)
EC50
170±n/a nM
Citation
 Monforte, AM; De Luca, L; Buemi, MR; Agharbaoui, FE; Pannecouque, C; Ferro, S Structural optimization of N Bioorg Med Chem 26:661-674 (2018) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50454272
Synonyms:
CHEMBL4211084
Type:
Small organic molecule
Emp. Form.:
C25H23N3O5S2
Mol. Mass.:
509.597
SMILES:
COC(=O)c1ccc(NC(=O)CSc2nc3ccccc3n2S(=O)(=O)c2cc(C)cc(C)c2)cc1
Structure:
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