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Target
Potassium voltage-gated channel subfamily A member 6
Ligand
BDBM50456970
Substrate
n/a
Meas. Tech.
ChEMBL_1758564 (CHEMBL4193572)
IC50
7900±n/a nM
Citation
 Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem 139:232-241 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 6
Synonyms:
KCNA6 | KCNA6_HUMAN | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.6
Type:
PROTEIN
Mol. Mass.:
58711.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_92811
Residue:
529
Sequence:
MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV
  
Inhibitor
Name:
BDBM50456970
Synonyms:
CHEMBL3261431
Type:
Small organic molecule
Emp. Form.:
C15H14FN5O
Mol. Mass.:
299.303
SMILES:
Nc1nc(\C=C\CNC(=O)c2cc3cc(F)ccc3[nH]2)c[nH]1
Structure:
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