Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50048280
Substrate
n/a
Meas. Tech.
ChEMBL_1760055 (CHEMBL4195063)
EC50
3.1±n/a nM
Citation
Thoreau, E; Arlabosse, JM; Bouix-Peter, C; Chambon, S; Chantalat, L; Daver, S; Dumais, L; Duvert, G; Feret, A; Ouvry, G; Pascau, J; Raffin, C; Rodeville, N; Soulet, C; Tabet, S; Talano, S; Portal, T Structure-based design of Trifarotene (CD5789), a potent and selective RAR? agonist for the treatment of acne. Bioorg Med Chem Lett 28:1736-1741 (2018) [PubMed] Article
More Info.:
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
Inhibitor
Name:
BDBM50048280
Synonyms:
6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid | 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid | ADAPALENE | CHEMBL1265
Type:
Small organic molecule
Emp. Form.:
C28H28O3
Mol. Mass.:
412.5201
SMILES:
COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:7:8:11:15.14.13,THB:9:10:13:17.8.16,9:8:11.10.15:13,16:8:11:15.14.13,16:14:11:17.9.8|