Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha
Ligand
BDBM50460101
Substrate
n/a
Meas. Tech.
ChEMBL_1768649 (CHEMBL4220761)
EC50
78±n/a nM
Citation
 Haffez, H; Chisholm, DR; Tatum, NJ; Valentine, R; Redfern, C; Pohl, E; Whiting, A; Przyborski, S Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids. Bioorg Med Chem 26:1560-1572 (2018) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50460101
Synonyms:
CHEMBL4226389
Type:
Small organic molecule
Emp. Form.:
C17H13NO2S
Mol. Mass.:
295.356
SMILES:
Cc1sc(nc1-c1ccccc1)-c1ccc(cc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: