Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50460100
Substrate
n/a
Meas. Tech.
ChEMBL_1768651 (CHEMBL4220763)
EC50
847±n/a nM
Citation
 Haffez, H; Chisholm, DR; Tatum, NJ; Valentine, R; Redfern, C; Pohl, E; Whiting, A; Przyborski, S Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids. Bioorg Med Chem 26:1560-1572 (2018) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50460100
Synonyms:
CHEMBL4226854
Type:
Small organic molecule
Emp. Form.:
C27H31NO2S
Mol. Mass.:
433.606
SMILES:
CCOC(=O)c1ccc(cc1)-c1nc(c(C)s1)-c1ccc2c(c1)C(C)(C)CCC2(C)C
Structure:
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