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Target
D-amino-acid oxidase
Ligand
BDBM50008990
Substrate
n/a
Meas. Tech.
ChEMBL_1768986 (CHEMBL4221098)
Kd
4430±n/a nM
Citation
 Szilágyi, B; Kovács, P; Ferenczy, GG; Rácz, A; Németh, K; Visy, J; Szabó, P; Ilas, J; Balogh, GT; Monostory, K; Vincze, I; Tábi, T; Szök?, É; Keser?, GM Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. Bioorg Med Chem 26:1579-1587 (2018) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-Amino Acid Oxidase (DAAO) | D-amino-acid oxidase (DAAO) | DAMOX | DAO | OXDA_PIG
Type:
Flavoprotein
Mol. Mass.:
39338.01
Organism:
Sus scrofa (pig)
Description:
Homodimer.
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPYIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFRPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLTMPPSHL
  
Inhibitor
Name:
BDBM50008990
Synonyms:
1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEMBL276725
Type:
Small organic molecule
Emp. Form.:
C7H6N2O
Mol. Mass.:
134.1353
SMILES:
O=c1[nH][nH]c2ccccc12
Structure:
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