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Target
NAD-dependent protein deacetylase sirtuin-7
Ligand
BDBM50463739
Substrate
n/a
Meas. Tech.
ChEMBL_1779305 (CHEMBL4236297)
Ki
>10000±n/a nM
Citation
 Fournier, JF; Bhurruth-Alcor, Y; Musicki, B; Aubert, J; Aurelly, M; Bouix-Peter, C; Bouquet, K; Chantalat, L; Delorme, M; Drean, B; Duvert, G; Fleury-Bregeot, N; Gauthier, B; Grisendi, K; Harris, CS; Hennequin, LF; Isabet, T; Joly, F; Lafitte, G; Millois, C; Morgentin, R; Pascau, J; Piwnica, D; Rival, Y; Soulet, C; Thoreau, É; Tomas, L Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma. Bioorg Med Chem Lett 28:2985-2992 (2018) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-7
Synonyms:
NAD-dependent protein deacetylase sirtuin-7 (SIRT7) | SIR2L7 | SIR7_HUMAN | SIRT7
Type:
Protein
Mol. Mass.:
44925.61
Organism:
Homo sapiens (Human)
Description:
Q9NRC8
Residue:
400
Sequence:
MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRGCTKRTKRKKVT
  
Inhibitor
Name:
BDBM50463739
Synonyms:
CHEMBL4237803
Type:
Small organic molecule
Emp. Form.:
C17H21N3O5
Mol. Mass.:
347.3657
SMILES:
COc1ccc(Nc2c(NCCCCCC(=O)NO)c(=O)c2=O)cc1
Structure:
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