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Target
Dihydroorotate dehydrogenase (fumarate)
Ligand
BDBM50466096
Substrate
n/a
Meas. Tech.
ChEMBL_1791599 (CHEMBL4263518)
IC50
31623±n/a nM
Citation
 Chibli, LA; Schmidt, TJ; Nonato, MC; Calil, FA; Da Costa, FB Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. Eur J Med Chem 157:852-866 (2018) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (fumarate)
Synonyms:
1.3.98.1 | DHODH | Dihydroorotate dehydrogenase (fumarate) | Dihydroorotate oxidase
Type:
PROTEIN
Mol. Mass.:
34659.43
Organism:
Leishmania major
Description:
ChEMBL_118088
Residue:
320
Sequence:
MSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPALREGNPTPRYQALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVATEKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQTLDEFRGKVRTLDGTAESTR
  
Inhibitor
Name:
BDBM50466096
Synonyms:
CHEMBL4278902
Type:
Small organic molecule
Emp. Form.:
C21H26O10
Mol. Mass.:
438.4251
SMILES:
[H][C@]12O[C@]1(C)CCC(=O)[C@@](C)(C[C@H](OC(C)=O)C1=C(COC(C)=O)C(=O)O[C@]21[H])OC(C)=O |r,c:18|
Structure:
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