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Target
Dihydroorotate dehydrogenase (fumarate)
Ligand
BDBM50466118
Substrate
n/a
Meas. Tech.
ChEMBL_1791599 (CHEMBL4263518)
IC50
316228±n/a nM
Citation
 Chibli, LA; Schmidt, TJ; Nonato, MC; Calil, FA; Da Costa, FB Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. Eur J Med Chem 157:852-866 (2018) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (fumarate)
Synonyms:
1.3.98.1 | DHODH | Dihydroorotate dehydrogenase (fumarate) | Dihydroorotate oxidase
Type:
PROTEIN
Mol. Mass.:
34659.43
Organism:
Leishmania major
Description:
ChEMBL_118088
Residue:
320
Sequence:
MSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPALREGNPTPRYQALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVATEKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQTLDEFRGKVRTLDGTAESTR
  
Inhibitor
Name:
BDBM50466118
Synonyms:
CHEMBL4290649
Type:
Small organic molecule
Emp. Form.:
C20H24O6
Mol. Mass.:
360.401
SMILES:
[H][C@]12C[C@@]3(C)OC(=CC3=O)\C(C)=C/[C@@]3([H])OC(=O)[C@@](C)([C@]13[H])[C@](O)(O2)C(\C)=C/C |r,c:6,12|
Structure:
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