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Target
Protein mono-ADP-ribosyltransferase PARP16
Ligand
BDBM199181
Substrate
n/a
Meas. Tech.
ChEMBL_1800459 (CHEMBL4272751)
IC50
4200±n/a nM
Citation
 Murthy, S; Desantis, J; Verheugd, P; Maksimainen, MM; Venkannagari, H; Massari, S; Ashok, Y; Obaji, E; Nkizinkinko, Y; Lüscher, B; Tabarrini, O; Lehtiö, L 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem 156:93-102 (2018) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP16
Synonyms:
2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 15 | ARTD15 | C15orf30 | Mono [ADP-ribose] polymerase PARP16 | PAR16_HUMAN | PARP-16 | PARP16 | Poly [ADP-ribose] polymerase 16 | Synonyms=ARTD15
Type:
PROTEIN
Mol. Mass.:
36398.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117586
Residue:
322
Sequence:
MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR
  
Inhibitor
Name:
BDBM199181
Synonyms:
4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
Type:
Small organic molecule
Emp. Form.:
C14H12N2O3
Mol. Mass.:
256.2567
SMILES:
NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1
Structure:
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