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Target
Pyroglutamylated RF-amide peptide receptor
Ligand
BDBM50469453
Substrate
n/a
Meas. Tech.
ChEMBL_1804125 (CHEMBL4276417)
EC50
1370±n/a nM
Citation
 Alim, K; Lefranc, B; Sopkova-de Oliveira Santos, J; Dubessy, C; Picot, M; Boutin, JA; Vaudry, H; Chartrel, N; Vaudry, D; Chuquet, J; Leprince, J Design, Synthesis, Molecular Dynamics Simulation, and Functional Evaluation of a Novel Series of 26RFa Peptide Analogues Containing a Mono- or Polyalkyl Guanidino Arginine Derivative. J Med Chem 61:10185-10197 (2018) [PubMed]  Article 
Target
Name:
Pyroglutamylated RF-amide peptide receptor
Synonyms:
GPR103 | Pyroglutamylated RFamide peptide receptor | QRFPR | QRFPR_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49508.46
Organism:
Homo sapiens (Human)
Description:
GPR103 0 HUMAN::Q96P65
Residue:
431
Sequence:
MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
  
Inhibitor
Name:
BDBM50469453
Synonyms:
CHEMBL4287860
Type:
Small organic molecule
Emp. Form.:
C42H57N11O8
Mol. Mass.:
843.9709
SMILES:
CCNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Structure:
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