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Target
Neuromedin-K receptor
Ligand
BDBM50470591
Substrate
n/a
Meas. Tech.
ChEMBL_209387 (CHEMBL857873)
Ki
79433±n/a nM
Citation
 Smith, PW; Cooper, AW; Bell, R; Beresford, IJ; Gore, PM; McElroy, AB; Pritchard, JM; Saez, V; Taylor, NR; Sheldrick, RL New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists. J Med Chem 38:3772-9 (1995) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49456.44
Organism:
GUINEA PIG
Description:
Neurokinin NK3 TACR3 GUINEA PIG::P30098
Residue:
440
Sequence:
MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS
  
Inhibitor
Name:
BDBM50470591
Synonyms:
CHEMBL124208
Type:
Small organic molecule
Emp. Form.:
C24H26FN3O2
Mol. Mass.:
407.4805
SMILES:
Fc1ccc2[nH]cc(CCN3CCC4(CN(Cc5ccccc5)C(=O)O4)CC3)c2c1
Structure:
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